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A Qui k Overview of QUARK

SERT Models of Emotional Dysregulation

The serotonin system plays a key modulatory role in central nervous system processes that appear to be dysregulated in psychiatric disorders. Specifically, the serotonin transporter (SERT) is thought to be critical to many aspects of emotional dysregulation, and has been a successful target for medications that treat several psychiatric disorders. Here, we narrowly focused on two psychiatric co...

Ppcdt / Qui / 58985 / 2004 Pi

I became PI for this project in August 2006, following the sad loss of Professor António Xavier. At the time, Pedro Quintas was employed by this project as a BI and he had been given extensive training in biophysical methods. Our first priority was the production of a series of mutants of cytochrome c” from Methylophilus methylotrophus designed to probe the mechanism of ligand exchange. Despite...

Approximating the Limiting Qui ksort

L'arbre qui cache la forêt

Le lupus est une pathologie chronique, qui évolue par poussées. Son expression clinique est très polymorphe et chaque symptôme peut être inaugural. Il peut débuter dès l'enfance, ces formes sont rares et de pronostic sévère. Le déficit en fractions du complément constitue l'un des principaux facteurs génétiques prédisposant au lupus érythémateux systémique. Nous rapportons un cas de lupus éryth...